Columnar distribution of serotonin-dependent plasticity within kitten striate cortex

AUTOR(ES)

Kojic, Ljubomir

FONTE

The National Academy of Sciences

RESUMO

Recent studies have identified the potential for an important role for serotonin (5-HT) receptors in the developmental plasticity of the kitten visual cortex. 5-HT2C receptors are transiently expressed in a patchy fashion in the visual cortex of kittens between 30–80 days of age complementary to patches demarcated by cytochrome oxidase staining. 5-HT, operating via 5-HT2C receptors, increases cortical synaptic plasticity as assessed both in brain slices and in vivo. Herein, we report that bath application of 5-HT substantially increases the probability of long-term potentiation within 5-HT2C receptor-rich zones of cortex, but this effect is not observed in the 5-HT2C receptor-poor zones. Instead, in these zones, 5-HT application increases the probability of long-term depression. These location-specific effects of 5-HT may promote the formation of compartment-specific cortical responses.

Documentos Relacionados

• The development of spatial-frequency selectivity in kitten striate cortex.
• Central gating of developmental plasticity in kitten visual cortex
• Long axons within the striate cortex: their distribution, orientation, and patterns of connection.
• Noradrenaline and functional plasticity in kitten visual cortex: a re-examination.
• Effects of nerve growth factor on neuronal plasticity of the kitten visual cortex.