Collagen fibril diameter distribution in patellar tendon autografts after posterior cruciate ligament reconstruction in sheep: changes over time.

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RESUMO

The alterations in collagen fibril diameter distribution, mean fibril diameter and the area occupied by collagen after posterior cruciate ligament reconstruction using a patellar tendon autograft were estimated 2, 6, 16, 26, 52 and 104 wk postoperatively. Patellar tendons and posterior cruciate ligaments from unoperated animals were used as control tissues. Collagen fibrils were divided into histograms according to their diameter in order to analyse distribution maxima. There was a significant decrease in mean fibril diameter of the grafts in comparison with the control tissues. At 104 wk it was only about 51% of that for control posterior cruciate ligaments. The total area occupied by collagen was significantly reduced at 6 wk postoperatively and was about 57% in comparison with normal posterior cruciate ligaments. A considerable increase of small diameter collagen fibrils together with a loss of large fibrils was responsible for these results. There was no evidence of reestablishment of large diameter fibrils, which are normally found in tendon and ligaments, up to 2 y after transplantation. The total area covered by collagen was still reduced at this stage although the number of fibrils had increased.

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