Collagen and Collagen-derived Fragments Are Chemotactic for Tumor Cells
AUTOR(ES)
Mundy, Gregory R.
RESUMO
Organs that are rich in collagen such as liver, lungs, and bone are frequently sites of tumor cell metastasis. In this study, we have found that cultured tumor cells of human and rat origin migrated unidirectionally in response to collagen in vitro. Synthetic di- and tri-peptides that contained amino acid sequences found frequently in the collagen helix caused similar effects. These results are consistent with the hypothesis that collagen or collagen fragments released during connective tissue remodeling may be important in tumor cell metastasis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=370899Documentos Relacionados
- Binding of Chemotactic Collagen-Derived Peptides to Fibroblasts: THE RELATIONSHIP TO FIBROBLAST CHEMOTAXIS
- Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides.
- A unique complement derived chemotactic factor for tumor cells.
- Chemotactic factor for tumor cells derived from the C5a fragment of complement component C5.
- T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritis