Coagulation and fibrinolysis in injured patients
AUTOR(ES)
Innes, D.
RESUMO
Serial changes in coagulation and fibrinolysis studied among 42 patients admitted to hospital with a wide variety of injuries are reported. The first hours after trauma are dominated by an acceleration of fibrinolysis (clot lysis) and clotting time which are often followed by an abrupt rebound to prolonged fibrinolysis and normal clotting. Evidence is presented that acceleration of fibrinolysis is due to flooding of the circulation by plasminogen activator and that prolongation is probably due to an inhibitor. A prolonged prothrombin time, increased prothrombin consumption index, an acceleration of the heparin-retarded clotting time, and a fall in the platelet count are also frequent during the first hours after injury. There is evidence also of an early deficiency in factor V and the onset of a fall in factor VII and prothrombin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=480663Documentos Relacionados
- Platelet function, coagulation and fibrinolysis in patients with previous coronary and cerebrovascular ischemic events
- Ultrasonic measurement of coagulation and fibrinolysis
- Coagulation fibrinolysis in sickle-cell disease
- Enhanced expression of genes involved in coagulation and fibrinolysis in murine arthritis
- Influence of protein C activation on blood coagulation and fibrinolysis in squirrel monkeys.
