Clostridium difficile-associated diarrhea in adults
AUTOR(ES)
Poutanen, Susan M.
RESUMO
CLOSTRIDIUM DIFFICILE is the most important cause of nosocomial diarrhea in adults. Illness may range from mild watery diarrhea to life-threatening colitis. An antecedent disruption of the normal colonic flora followed by exposure to a toxigenic strain of C. difficile are necessary first steps in the pathogenesis of disease. Diagnosis is based primarily on the detection of C. difficile toxin A or toxin B. First-line treatment is with oral metronidazole therapy. Treatment with oral vancomycin therapy should be reserved for patients who have contraindications or intolerance to metronidazole or who fail to respond to first-line therapy.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=437686Documentos Relacionados
- Epidemiology of Recurrences or Reinfections of Clostridium difficile-Associated Diarrhea
- Commercial latex agglutination test for detection of Clostridium difficile-associated diarrhea.
- Rifalazil Treats and Prevents Relapse of Clostridium difficile-Associated Diarrhea in Hamsters
- Molecular Analysis of Clostridium difficile Strains Isolated from 18 Cases of Recurrent Clostridium difficile-Associated Diarrhea
- Treatment of Clostridium difficile-associated disease with teicoplanin.
