Clock is important for food and circadian regulation of macronutrient absorption in mice

AUTOR(ES)

Pan, Xiaoyue

FONTE

The American Society for Biochemistry and Molecular Biology

RESUMO

Clock genes respond to external stimuli and exhibit circadian rhythms. This study investigated the expression of clock genes in the small intestine and their contribution in the regulation of nutrient absorption by enterocytes. We examined expression of clock genes and macronutrient transport proteins in the small intestines of wild-type and Clock mutant (Clkmt/mt) mice with free or limited access to food. In addition, we studied absorption of macronutrients in these mice. Intestinal clock genes show circadian expression and respond to food entrainment in wild-type mice. Dominant negative Clock in Clkmt/mt mice disrupts circadian expression and food entrainment of clock genes. The absorption of lipids and monosaccharides was high in Clkmt/mt mice whereas peptide absorption was reduced. Molecular studies revealed that Clock regulates several transport proteins involved in nutrient absorption. Clock plays an important role in light and food entrainment of intestinal functions by regulating nutrient transport proteins. Disruptions in intestinal circadian activity may contribute to hyperlipidemia and hyperglycemia.

Documentos Relacionados

• Regulation of prokineticin 2 expression by light and the circadian clock
• Mathematical Model of the Drosophila Circadian Clock: Loop Regulation and Transcriptional Integration
• Differential regulation of circadian pacemaker output by separate clock genes in Drosophila
• Regulation of the Neurospora circadian clock by casein kinase II
• Regulation of the Neurospora circadian clock by an RNA helicase