Clinical significance of the isolation of Candidaspecies from hospitalized patients
AUTOR(ES)
Magalhães, Yankee C., Bomfim, Maria Rosa Q., Melônio, Luciane C., Ribeiro, Patrícia C.S., Cosme, Lécia M., Rhoden, Cristianne R., Marques, Sirlei G.
FONTE
Braz. J. Microbiol.
DATA DE PUBLICAÇÃO
31/03/2015
RESUMO
In this study, we isolated and phenotypically identified 108 yeast strains from various clinical specimens collected from 100 hospitalized patients at three tertiary hospitals in São Luís-Maranhão, Brazil, from July to December 2010. The isolates were analyzed for their susceptibility to four of the most widely used antifungal agents in the surveyed hospitals, amphotericin B, fluconazole, 5-flucytosine and voriconazole. The species identified were Candida albicans (41.4%), Candida tropicalis (30.1%), C. glabrata (7.4%), Candida parapsilosis(5.5%), Candida krusei (4.6%), Cryptococcus neoformans (4.6%), Trichosporonspp. (3.7%), Candida norvegensis (0.9%), Rhodotorula glutinis (0.9%) and Pichia farinosa (0.9%). A higher isolation rate was observed in the following clinical specimens: urine (54 isolates; 50%), respiratory tract samples (21 isolates; 19.4%) and blood (20 isolates; 18.6%). Candida albicans isolates were 100% sensitive to all antifungal agents tested, whereas Candida krusei and Crytococcus neoformans displayed intermediate resistance to 5-flucytosine, with Minimal Inhibitory Concentration (MIC) values of 8 mg/mL and 16 mg/mL, respectively. Both strains were also S-DD to fluconazole with an MIC of 16 mg/mL. C. tropicalis was resistant to 5-flucytosine with an MIC of 32 μg/mL. This study demonstrates the importance of identifying the yeast species involved in community and nosocomial infections.
Documentos Relacionados
- Isolation of Clostridium difficile from hospitalized patients without antibiotic-associated diarrhea or colitis.
- Clinical diagnosis of hyposalivation in hospitalized patients
- Clinical significance of Aeromonas species isolated from patients with diarrhea.
- Isolation and Characterization of Glycopeptide-Resistant Enterococci from Hospitalized Patients over a 30-Month Period
- Trace Components of Plasma: Isolation and Clinical Significance