Clinical significance of human papillomavirus infection of the uterine cervix in the development of cervical intraepithelial neoplasia.
AUTOR(ES)
Cheetham, D
RESUMO
A group of 25 controls and 30 women with lesions of the cervix associated with papillomavirus were studied prospectively by colposcopy and cytology for up to two years to investigate the relation between human papillomavirus (HPV) infection of the cervix and resolution or progression of cervical intraepithelial neoplasia (CIN). We found that the viral changes were transient and that active infection, as judged by repeated colposcopic and cytological examination, resolved in 83% of the patients. Resolution or persistence of the viral infection did not appear to affect the development of the CIN lesion. The proportion of CIN lesions that resolved and persisted were the same for the study group and the controls. Possible reactivation of latent papillomavirus was noted in three control group patients. Our findings indicate that changes in the cervix associated with papillomavirus should not influence the clinical management or follow up of patients with CIN.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1046296Documentos Relacionados
- Condylomata of the uterine cervix and koilocytosis of cervical intraepithelial neoplasia.
- Cervical intraepithelial neoplasia.
- Cervical intraepithelial glandular neoplasia.
- Comparison of prevalence of human papillomavirus antigen in biopsies from women with cervical intraepithelial neoplasia.
- Human papillomavirus infection of the uterine cervix of women without cytological signs of neoplasia