Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil

AUTOR(ES)

Beirão, Elisa Maria, Furtado, Juvencio Jose Duailibe, Girardello, Raquel, Ferreira Filho, Heli, Gales, Ana Cristina

FONTE

Brazilian Journal of Infectious Diseases

DATA DE PUBLICAÇÃO

2011-02

RESUMO

In 2008 isolates of KPC-producing Klebsiella pneumoniae (KPC-KPN) were detected for the first time at Hospital Heliópolis, São Paulo, Brazil. The aim of this study was to characterize the clinical and microbiological outcomes of infections caused by KPC-KPN. A historical cohort of patients from whom KPC-KPN strains were isolated was performed. Isolates were identified as resistant to ertapenem by automated broth microdilution system and screened as carbapenemase producers by the modified Hodge test. The beta-lactamase resistance gene blaKPC was detected by PCR. The genetic relatedness of isolates was determined by PFGE. The study provides early clinical experience in treating KPC-KPN infections in a Brazilian tertiary center.

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