Clinical and autoantibody correlations in Orientals with systemic lupus erythematosus.

AUTOR(ES)

Boey, M L

RESUMO

Serum samples from 94 patients with systemic lupus erythematosus (SLE) from a medical unit in Singapore were analysed for autoantibodies of 10 different specificities. The prevalence of antibodies to the following antigens was as follows: double stranded (ds) DNA (43%), histone (81%), Sm (26%), nuclear ribonuclear protein (nRNP) (32%), SS-A(Ro) (63%), SS-B(La) (12%), SL/Ki (9%), ribosomal RNP (rRNP) (16%), p70/p80 (5%), proliferating cell nuclear antigen (PCNA) (3%). Except for a higher prevalence of anti-SS-A(Ro), other autoantibodies were within the range reported from Western countries, indicating a high uniformity of autoantibody profiles in SLE in different countries. Patients with neuropsychiatric manifestations showed a higher plurality of antibodies per patient than patients without neuropsychiatric symptoms, 4.22 v 2.77. Patients with anti-Sm were more likely to have active lupus disease. There was no increased prevalence or specific type of autoantibody in those with renal manifestations.

Documentos Relacionados

• Lupus anticoagulant: clinical significance in anticardiolipin positive patients with systemic lupus erythematosus.
• Clinical and radiological features of osteonecrosis in systemic lupus erythematosus.
• Tuberculosis in patients with systemic lupus erythematosus.
• Amyloidosis and systemic lupus erythematosus.
• Toxoplasmosis and systemic lupus erythematosus.