Cleft lip with or without cleft palate: implication of the heavy chain of non‐muscle myosin IIA

AUTOR(ES)

Martinelli, Marcella

FONTE

BMJ Group

RESUMO

Non‐syndromic cleft lip with or without palate (CL/P) is one of the most common malformations among live births, but most of the genetic components and environmental factors involved remain to be identified. Among the different causes, MYH9, the gene encoding for the heavy chain of non‐muscle myosin IIA, was considered a potential candidate, because it was found to be abundantly and specifically expressed in epithelial cells of palatal shelves before fusion. After fusion, its expression level was shown to decrease and to become limited to epithelial triangles before disappearing, as fusion is completed.

Documentos Relacionados

• Identification of the gene for fly non-muscle myosin heavy chain: Drosophila myosin heavy chains are encoded by a gene family.
• Cleft lip with or without cleft palate: identification of sporadic cases with a high level of genetic predisposition.
• Erratum: Identification of the gene for fly non-muscle myosin heavy chain: Drosophila myosin heavy chains are encoded by a gene family
• Exclusion of candidate genes from a role in cleft lip with or without cleft palate: linkage and association studies.
• The 19-bp deletion polymorphism of dihydrofolate reductase (DHFR) and nonsyndromic cleft lip with or without cleft palate: evidence for a protective role