ClC chloride channels
AUTOR(ES)
Mindell, Joe
FONTE
BioMed Central
RESUMO
Chloride-conducting ion channels of the ClC family are emerging as critical contributors to a host of biological processes. These polytopic membrane proteins form aqueous pathways through which anions are selectively allowed to pass down their concentration gradients. The ClCs are found in nearly all organisms, with members in every mammalian tissue, yet relatively little is known about their mechanism or regulation. It is clear, however, that they are fundamentally different in molecular construction and mechanism from the well-known potassium-, sodium-, and calcium-selective channels. The medical importance of ClC channels - four inherited diseases have been blamed on familial ClC dysfunction to date - highlights their diverse physiological functions and provides strong motivation for further study.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=138906Documentos Relacionados
- Chloride channels and endocytosis: ClC-5 makes a Dent
- Isolation and Characterization of a High Affinity Peptide Inhibitor of ClC-2 Chloride Channels*
- The swelling-activated chloride channel ClC-2, the chloride channel ClC-3, and ClC-5, a chloride channel mutated in kidney stone disease, are expressed in distinct subpopulations of renal epithelial cells.
- Analysis of ClC-2 channels as an alternative pathway for chloride conduction in cystic fibrosis airway cells
- ClC-5 chloride channel and kidney stones: what is the link?