Cladistic association analysis of Y chromosome effects on alcohol dependence and related personality traits
AUTOR(ES)
Kittles, Rick A.
FONTE
The National Academy of Sciences
RESUMO
Association between Y chromosome haplotype variation and alcohol dependence and related personality traits was investigated in a large sample of psychiatrically diagnosed Finnish males. Haplotypes were constructed for 359 individuals using alleles at eight loci (seven microsatellite loci and a nucleotide substitution in the DYZ3 alphoid satellite locus). A cladogram linking the 102 observed haplotype configurations was constructed by using parsimony with a single-step mutation model. Then, a series of contingency tables nested according to the cladogram hierarchy were used to test for association between Y haplotype and alcohol dependence. Finally, using only alcohol-dependent subjects, we tested for association between Y haplotype and personality variables postulated to define subtypes of alcoholism—antisocial personality disorder, novelty seeking, harm avoidance, and reward dependence. Significant association with alcohol dependence was observed at three Y haplotype clades, with significance levels of P = 0.002, P = 0.020, and P = 0.010. Within alcohol-dependent subjects, no relationship was revealed between Y haplotype and antisocial personality disorder, novelty seeking, harm avoidance, or reward dependence. These results demonstrate, by using a fully objective association design, that differences among Y chromosomes contribute to variation in vulnerability to alcohol dependence. However, they do not demonstrate an association between Y haplotype and the personality variables thought to underlie the subtypes of alcoholism.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=22445Documentos Relacionados
- Personality traits and psychiatric comorbidities in alcohol dependence
- Personality traits, alcohol and cannabis use among medical students
- Nonhuman primate model of alcohol abuse: effects of early experience, personality, and stress on alcohol consumption.
- The association of major depressive episode and personality traits in patients with fibromyalgia
- Drosophila Male-Specific Lethal-2 Protein: Structure/Function Analysis and Dependence on Msl-1 for Chromosome Association