Chemoresistance in human ovarian cancer: the role of apoptotic regulators
AUTOR(ES)
Fraser, Michael
FONTE
BioMed Central
RESUMO
Ovarian cancer is among the most lethal of all malignancies in women. While chemotherapy is the preferred treatment modality, chemoresistance severely limits treatment success. Recent evidence suggests that deregulation of key pro- and anti-apoptotic pathways is a key factor in the onset and maintenance of chemoresistance. Furthermore, the discovery of novel interactions between these pathways suggests that chemoresistance may be multi-factorial. Ultimately, the decision of the cancer cell to live or die in response to a chemotherapeutic agent is a consequence of the overall apoptotic capacity of that cell. In this review, we discuss the biochemical pathways believed to promote cell survival and how they modulate chemosensitivity. We then conclude with some new research directions by which the fundamental mechanisms of chemoresistance can be elucidated.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=270001Documentos Relacionados
- Cervical cancer: epidemiology, prevention and the role of human papillomavirus infection
- Role of CT scan-based and clinical evaluation in the preoperative prediction of optimal cytoreduction in advanced ovarian cancer: a prospective trial
- The role of bisphosphonates in breast cancer: Development of bisphosphonates
- Prostasin, a potential tumor marker in ovarian cancer: a pilot study
- Role of primary surgery in advanced ovarian cancer
