Chemoenzymatic Synthesis and Anti-Inflammatory Activity of Fatty Acid Amides Prepared from Bertholletia excelsa (Brazil Nut) Triglycerides

AUTOR(ES)

Barata, Pedro H. S.; Sarquis, Ícaro R.; Carvalho, Helison O.; Barros, Albenise S.; Rodrigues, Alex B.; Galue-Parra, Adan J.; Silva, Edilene O.; Carvalho, José Carlos T.; Ferreira, Irlon M.

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2020-08

RESUMO

This study reports the synthesis of fatty acid amides (FAA), analogous to anandamide, prepared from Brazil nut oil (BNO), using Amano lipase from Pseudomonas fluorescens as a catalyst of direct aminolysis, with a good yield (95-68%). The anti-inflammatory effects of BNO and FAA were evaluated by the carrageenan-induced paw edema method. Analysis of the formation of edema showed that these FAA, at all dose used, significantly reduced the development of edema.

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