Chemiosmotic Mechanism of Antimicrobial Activity of Ag+ in Vibrio cholerae

AUTOR(ES)

Dibrov, Pavel

FONTE

American Society for Microbiology

RESUMO

Although the antimicrobial effects of silver salts were noticed long ago, the molecular mechanism of the bactericidal action of Ag+ in low concentrations has not been elucidated. Here, we show that low concentrations of Ag+ induce a massive proton leakage through the Vibrio cholerae membrane, which results in complete deenergization and, with a high degree of probability, cell death.

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