Chemical Study of the antagonistic fungus Trichoderma harzianum / Estudo Químico do Fungo Antagonista Trichoderma harzianum

AUTOR(ES)

Natália Nogueira Saraiva

DATA DE PUBLICAÇÃO

2009

RESUMO

The chemical potential of Trichoderma harzianum, an antagonist fungus, was investigated. The fatty acid composition of this fungus grown in Czapeck, peptone and potato, with different carbon source (glycose and manitol) in the later medium, was determined after GC/MS analysis. The following fatty acids, as their methyl esters, were identified: hexadecanoic (C16:0), octadecanoic (C18:0), 9-octadecenoic (C18:1) and 9,12-octadienoic (C18:2). From the organic extracts of the microorganism cultivated in peptone (16 days) and potatodextrose (21 days) broths, manitol and the antimicrobial viridiofungin A were isolated, respectively. Extracts and fractions were submitted to antitumor assays against the human cell tumor lines MDA-MB435 (mama), HCT-8 (colon) e SF-295 (glioblastoma) and five of them showed IC50 75 % in two or three cell lines. Alcohol dehydrogenases (ADHs) activity of T. harzianum was identified and this microorganism was used as biocatalyst in the reduction of (R)-carvone, acetophenone and six akylphenones. In most cases, the products of the bioreductions were obtained.

ASSUNTO(S)

viridiofungin a ácidos graxos bioreductions viridiofungina a quimica trichoderma harzianum fatty acids biorredução. trichoderma harzianum

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