Chemical modifications of a natural xanthone and antimicrobial activity against multidrug resistant Staphylococcus aureus and cytotoxicity against human tumor cell lines
AUTOR(ES)
Micheletti, Ana Camila, Honda, Neli Kika, Lima, Dênis Pires de, Beatriz, Adilson, Sant'ana, Maria Rita, Carvalho, Nadia Cristina Pereira, Matos, Maria de Fatima Cepa, Queiróz, Lyara Meira Marinho, Bogo, Danielle, Zorzatto, José Roberto
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2011
RESUMO
A series of 15 ω-aminoalkoxylxanthones containing methyl, ethyl, propyl, tert-butylamino and piperidinyl moieties were synthesized from a natural xanthone isolated from a lichen species. These compounds were tested for their in vitro antibacterial properties against Gram-positive and Gram-negative bacteria and cytotoxicity against a number of human tumor cell lines was too evaluated. The newly synthesized derivatives revealed selective activity against Staphylococcus aureus (Gram-positive), and the most promising results are for a multidrug resistant strain, for which six of these compounds showed good activity (MICs 4 µg/mL). Many derivatives inhibited tumor cells growth and most compounds were active on multiple lines.
Documentos Relacionados
- Antimicrobial activity of Melaleuca sp. oil against clinical isolates of antibiotics resistant Staphylococcus aureus
- Antimicrobial activity of Melaleuca sp. oil against clinical isolates of antibiotics resistant Staphylococcus aureus
- Antimicrobial activity of SM-17466, a novel carbapenem antibiotic with potent activity against methicillin-resistant Staphylococcus aureus.
- Activity of ciprofloxacin against methicillin-resistant Staphylococcus aureus.
- In vitro activity of antimicrobial combinations against multidrug-resistant Pseudomonas aeruginosa