Chemical Constituents of the Seeds of Raphanus sativus and their Biological Activity
AUTOR(ES)
Kim, Ki Hyun, Moon, Eunjung, Lee, Seoung Rak, Park, Kyoung Jin, Kim, Sun Yeou, Choi, Sang Un, Lee, Kang Ro
FONTE
J. Braz. Chem. Soc.
DATA DE PUBLICAÇÃO
2015-11
RESUMO
As part of our ongoing search for bioactive constituents of natural Korean medicinal resources, a bioassay-guided fractionation and chemical investigation of the MeOH extract of Raphanus sativus (Brassicaceae) seeds resulted in the isolation and identification of fifteen compounds, including a new phenolic compound. The structure of the new compound was determined by extensive spectroscopic analysis and the Mosher's method. One of the compounds has been recently reported as a synthetic product. Some compounds showed moderate antiproliferative activities against the tumor cell lines A549, SK-OV-3, SK-MEL-2, and HCT-15 with IC50 values in the range of 5.62 to 28.88 μM. Moreover, the anti-neuroinflammatory activities of the isolates were determined by measuring the nitric oxide (NO) levels in the medium using murine microglia BV-2 cells. With exception of one specific compound, all the others inhibited the lipopolysaccharide (LPS)-stimulated NO production (IC50 values < 200 μM).
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