CHEMICAL CONSTITUENTS, ANTI-INFLAMMATORY, AND FREE-RADICAL SCAVENGING ACTIVITIES OF Guettarda viburnoides CHAM. & SCHLTDL. (RUBIACEAE)

AUTOR(ES)

Naressi, Maria Augusta, Manholer, Daniele Domingos, Ames, Franciele Queiroz, Bersani-Amado, Ciomar Aparecida, Formagio, Anelise Samara Nazari, Pereira, Zefa Valdivina, Costa, Willian Ferreira da, Baldoqui, Debora Cristina, Sarragiotto, Maria Helena

FONTE

Quím. Nova

DATA DE PUBLICAÇÃO

2015-08

RESUMO

Chemical investigation of Guettarda viburnoides (leaves) led to the isolation of ursolic acid, uncaric acid, secoxyloganin, and grandifloroside, along with a mixture of quercetin-3-O-β-D-galactopyranoside and quercetin-3-O-β-D-glucopyranoside, and of β-sitosterol and stigmasterol. The structures of the isolated compounds were elucidated on the basis of their NMR data. The crude extract, ethyl acetate fraction, aqueous-methanol fraction, and grandifloroside showed significant DPPH free-radical scavenging activities with IC50 ranging from 18.92 to 26.47 µg mL-1. The topical administration of the crude extract and fractions markedly reduced the croton oil-induced mice ear edema in 67.0%-99.0%. Inhibition of tissue MPO activity was also observed, which demonstrated an anti-inflammatory effect of the G. viburnoides species.

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