Characterization of Escherichia coli Mutants Tolerant to Bacteriocin JF246: Two New Classes of Tolerant Mutants
AUTOR(ES)
Foulds, John
RESUMO
Several hundred independent bacteriocin-tolerant mutants have been isolated without mutagenesis from three strains of Escherichia coli. On the basis of patterns of sensitivity to eight different colicins, over 85% of these mutants could be grouped into four classes. Two classes of mutants, class A and class B, are equivalent to tolA and tolB type mutants. We found tolA and tolB mutants were sensitive to the antibiotic bacitracin. The other two classes of bacteriocin-tolerant mutants, class F and class G, are distinguished from other types of colicin-tolerant mutants on the basis of sensitivity to colicins, dyes, detergents, antibiotics, and chelating agents. The mutation in class F and class G mutants is located between 21 to 23 min on the E. coli chromosome. We propose to designate the loci of these mutations as tolF and tolG, respectively.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=285459Documentos Relacionados
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