Characterization of Adenylate Cyclase-Hemolysin Gene Duplication in a Bordetella pertussis Isolate

AUTOR(ES)

Dalet, Karine

FONTE

American Society for Microbiology

RESUMO

We describe a clinical isolate of Bordetella pertussis, the agent responsible for whooping cough, composed of at least two clones harboring one or two copies of the cya locus encoding one of the major toxins, adenylate cyclase-hemolysin. No difference was observed between the two clones in murine and cellular models, probably due to the high instability of the cya locus duplication.

Documentos Relacionados

• Role of Adenylate Cyclase-Hemolysin in Alveolar Macrophage Apoptosis during Bordetella pertussis Infection In Vivo
• Bordetella pertussis Adenylate Cyclase-Hemolysin Induces Interleukin-6 Secretion by Human Tracheal Epithelial Cells
• Bordetella pertussis induces apoptosis in macrophages: role of adenylate cyclase-hemolysin.
• Virulence of Bordetella bronchiseptica: role of adenylate cyclase-hemolysin.
• The C-terminal domain is essential for protective activity of the Bordetella pertussis adenylate cyclase-hemolysin.