Characterization and in vitro release of cyclosporine-A from poly(D,L-lactide-co-glycolide implants obtained by solvent/extraction evaporation

AUTOR(ES)

Saliba, Juliana Barbosa, Silva-Cunha Junior, Armando da, Silva, Gisele Rodrigues da, Yoshida, Maria Irene, Mansur, Alexandra Ancelmo Piscitelli, Mansur, Herman Sander

FONTE

Química Nova

DATA DE PUBLICAÇÃO

2012

RESUMO

Cyclosporine-A-loaded PLGA implants were developed intended for ocular route. Implants were prepared using solvent extraction/evaporation technique followed by casting of the cake into rods in a heated surface. XRD patterns showed that cyclosporine-A was completely incorporated into PLGA. FTIR and DSC results indicated alterations on drug molecular conformation aiming to reach the most stable thermodynamic conformation at polymer/drug interface. Implants provided controlled/sustained in vitro release of the drug. During the first 7 weeks, the drug release was controlled by the diffusion of the cyclosporine-A; and between 7-23 week period, the drug diffusion and degradation of PLGA controlled the drug release.

Documentos Relacionados

• Identification of chemically modified peptide from poly(D,L-lactide-co-glycolide) microspheres under in vitro release conditions
• Preparation and characterization of poly(D,L-lactide-co-glycolide) microspheres for controlled release of human growth hormone
• Poly(D,L-Lactide-Co-Glycolide) microspheres containing 5-fluorouracil: Optimization of process parameters
• Adjuvanticity and protective immunity elicited by Bordetella pertussis antigens encapsulated in poly(DL-lactide-co-glycolide) microspheres.
• Drug release from microspheres and nanospheres of poly(lactide-co-glycolide) without sphere separation from the release medium