Changes in benzodiazepine receptor binding as seen autoradiographically in the central nervous system of the spastic mouse.
AUTOR(ES)
Biscoe, T J
RESUMO
Quantitative light-microscope autoradiography has been used to compare the specific, clonazepam-displaceable binding of [3H]flunitrazepam, a photoaffinity label for the 1,4-benzodiazepine receptor, in different regions of the brain and spinal cord of spastic mice and their unaffected littermates. Specific binding of [3H]flunitrazepam in the central nervous system of the spastic mouse showed significant increases in the anterior colliculus and pretectal area and in all laminae of the grey matter in the lumbar spinal cord. These results confirm homogenate binding assays suggesting an increased number of benzodiazepine receptors in the spinal cord of the spastic mouse. Possible sites are therefore provided at which disorders of function could arise, associated with changes seen at the gamma-aminobutyric acid (GABA)-benzodiazepine receptor complex in spinal cord homogenates from the mutant mouse spastic.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1193226Documentos Relacionados
- Autoradiography of benzodiazepine receptor binding in the central nervous system of the normal C57BL6J mouse.
- Expression of the Mouse Hepatitis Virus Receptor by Central Nervous System Microglia
- Gamma-Aminobutyric Acid Binding to Receptor Sites in the Rat Central Nervous System
- Effect of infection with the ts22 mutant of Semliki Forest virus on development of the central nervous system in the fetal mouse.
- Poliovirus Induces Apoptosis in the Mouse Central Nervous System