Cerebrospinal fluid concentration of fibronectin in patients with HIV-1 infection and central nervous system disorders.
AUTOR(ES)
Torre, D
RESUMO
AIMS--To evaluate the fibronectin concentrations in the cerebrospinal fluid of HIV-1 infected patients with central nervous system disorders. METHODS--Fibronectin was determined by an immunoturbidimetric assay in 41 HIV-1 infected patients with AIDS dementia complex, progressive multifocal leucoencephalopathy, and opportunistic infections. RESULTS--A significant decrease in fibronectin concentrations in the cerebrospinal fluid of patients with AIDS and dementia complex and progressive multifocal leucoencephalopathy was observed, as well as in those with opportunistic infections of the central nervous system (p < 0.0001). In particular, a significant decrease in fibronectin concentration in cerebrospinal fluid was observed in patients with cerebral toxoplasmosis and cryptococcal meningitis (p < 0.0001). CONCLUSIONS--Because fibronectin can bind to several viruses, fungi, and protozoa, it is conceivable to suppose that the consumption of fibronectin in the cerebrospinal fluid of patients with neurological disorders may be related to the binding of fibronectin to HIV itself, or to viral proteins, or to organisms responsible for opportunistic infections.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=501691Documentos Relacionados
- Apoptosis induced by HIV-1 infection of the central nervous system.
- Viral antibody in the cerebrospinal fluid of patients with acute central nervous system infections.
- Isolation of Inoue-Melnick virus and detection of antibodies in coded cerebrospinal fluid specimens from patients with disorders of the central nervous system.
- Cerebrospinal fluid vasopressin in neurological and psychiatric disorders.
- Cerebrospinal fluid analysis in patients with COVID-19-associated central nervous system manifestations: a systematic review
