Cerebral perfusion quantification using arterial spin labeling: applications in vascular territories measurement and functional imaging / Quantificação da perfusão sanguínea cerebral utilizando arterial spin labeling: aplicações em medidas de territórios vasculares e em imagens funcionais

AUTOR(ES)

Fernando Fernandes Paiva

DATA DE PUBLICAÇÃO

2008

RESUMO

Arterial spin labeling techniques allow to obtain quantitative maps of perfusion non-invasively. Along with other MRI techniques, it has proven useful for diagnosis of a variety of cerebrovascular diseases. Amongst the available basic implementations, the continuous approach employing a dedicated labeling RF coil has the advantages of presenting high signal-to-noise ratio and lower RF power deposition. In the present work, these advantages were explored in order to implement a methodology to obtain quantitative maps of cerebral blood flow and the vascular territories of the major cerebral feeding arteries. Human and animal results reveal the robustness and applicability of the technique in cerebral hemodynamic studies. Applications in hypertension show that the technique can provide complimentary information to improve the understanding of neurovascular diseases. The dynamic ASL technique shows the method versatility for studying the spatial and temporal characteristics of cerebral hemodynamics. The results unravel that both under basal and functional hyperemia conditions.

ASSUNTO(S)

magnetic resonance arterial spin labeling arterial spin labeling fluxo sanguíneo cerebral cerebral blood flow ressonância magnética

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