Cerebral mucormycosis in diabetic mice after intrasinus challenge.

AUTOR(ES)

Waldorf, A R

RESUMO

Rhinocerebral involvement is the most common form of mucormycosis in uncontrolled diabetic patients. Streptozotocin-induced diabetic and normal mice were challenged by intrasinus inoculation of Rhizopus oryzae to determine their susceptibility to infection by this route. Ninety percent of diabetic mice and no normal mice died after inoculation with 10(6) spores. Intrasinus inoculations caused minimal direct trauma and low levels of brain inocula, but progressive cerebral infections were induced in diabetic mice.

Documentos Relacionados

• Systemic and gastrointestinal candidiasis of infant mice after intragastric challenge.
• Angiostrongylus cantonensis: phospholipase in nonsensitized and sensitized rats after challenge.
• Immunity to Mycobacterium leprae infections induced in mice by BCG vaccination at different times before or after challenge.
• Experimental murine candidiasis: cell-mediated immunity after cutaneous challenge.
• Changes in bronchial responsiveness to histamine at intervals after allergen challenge.