Cerebral infarction related to cryptococcal meningitis in an HIV-infected patient: case report and literature review

AUTOR(ES)

Leite, Andréa Gurgel Batista, Vidal, José E., Bonasser Filho, Francisco, Nogueira, Roberta Schiavon, Oliveira, Augusto César Penalva de

FONTE

Brazilian Journal of Infectious Diseases

DATA DE PUBLICAÇÃO

2004-04

RESUMO

Neurological dysfunction as the first manifestation of AIDS has been found in 10 to 20% of symptomatic human immunodeficiency virus infections. However, stroke has rarely been reported in AIDS patients. The most common causes of cerebral infarction in AIDS are central nervous system infections: toxoplasmosis, cryptococcal meningitis and tuberculosis. Potential vascular mechanisms for cerebral infarction and transient neurological deficits among AIDS patients include deposition of antigen-antibody complexes with vasculitis and infarction, and a direct toxic effect of a viral antigen or infectious agent on vascular endothelium. The role of cryptococcal meningitis in vasculopathy is still not clear. We report a case of cerebral infarction in an HIV-infected patient, with cryptococcal meningitis as the first manifestation of AIDS.

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