Central role of the P2Y12 receptor in platelet activation

AUTOR(ES)

Dorsam, Robert T.

FONTE

American Society for Clinical Investigation

RESUMO

Platelet activation occurs in response to vessel injury and is important for the arrest of bleeding. Platelet activation during disease states leads to vascular occlusion and ischemic damage. The P2Y12 receptor, activated by ADP, plays a central role in platelet activation and is the target of P2Y12 receptor antagonists that have proven therapeutic value.

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