Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline

AUTOR(ES)

Isbil-Buyukcoskun, N., Gulec, G., Ozluk, K., Ulus, I.H.

FONTE

Brazilian Journal of Medical and Biological Research

DATA DE PUBLICAÇÃO

2001-06

RESUMO

In the present study, we investigated the involvement of the brain renin-angiotensin system in the effects of central cholinergic stimulation on blood pressure in conscious, freely moving normotensive rats. In the first step, we determined the effects of intracerebroventricular (icv) choline (50, 100 and 150 µg) on blood pressure. Choline increased blood pressure in a dose-dependent manner. In order to investigate the effects of brain renin-angiotensin system blockade on blood pressure increase induced by choline (150 µg, icv), an angiotensin-converting enzyme inhibitor, captopril (25 and 50 µg, icv), was administered 3 min before choline. Twenty-five µg captopril did not block the pressor effect of choline, while 50 µg captopril blocked it significantly. Our results suggest that the central renin-angiotensin system may participate in the increase in blood pressure induced by icv choline in normotensive rats.

Documentos Relacionados

• Cardiovascular effects of the intracerebroventricular injection of adrenomedullin: roles of the peripheral vasopressin and central cholinergic systems
• Cardiovascular responses to static exercise in conscious cats: effects of intracerebroventricular injection of clonidine.
• Response of the arterial blood pressure of quadriplegic patients to treadmill gait training
• Circulating microparticles and central blood pressure according to antihypertensive strategy
• Congestive cardiac failure: central role of the arterial blood pressure.