Cellular immunodeficiency related to chronic dermatophytosis in a patient with Schistosoma mansoni infection: can schistosomiasis induce immunodeficiency?

AUTOR(ES)

Ferreira, Maurício Domingues, Collaniere, Anna Cristina, Bertolini, Dalton Luís, Barros, Noac Chuffi, Vasconcelos, Dewton de Moraes

FONTE

Rev. Soc. Bras. Med. Trop.

DATA DE PUBLICAÇÃO

2017-02

RESUMO

Abstract: Here, we describe a case of hepatosplenic schistosomiasis that progressed to widespread persistent dermatophytosis. Significant T and B lymphocytopenia was confirmed. T-cell deficit is associated with increased susceptibility to fungal infections of skin and mucous membranes. The accumulation of a large amount of blood cells in the spleen could have played a crucial role in the development of lymphocytopenia in the present case. Alternatively, the schistosomiasis-induced increase in prostaglandin E2 levels could have inhibited the production of interferon-γ, a cytokine fundamental to fungal resistance. This case shows the potential of hepatosplenic schistosomiasis to impair the immune response.

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