Cell-mediated immunity to varicella-zoster virus demonstrated by viral inactivation with human leukocytes.
AUTOR(ES)
Gershon, A A
RESUMO
Cell-mediated immunity to varicella-zoster (V-Z) virus in persons immune to varicella has been demonstrated, using a tissue culture technique. Cell-mediated immunity was reflected by the ability of peripheral leukocytes (lymphocytes and monocytes) from human donors to inactivate V-Z virus. Leukocytes were stimulated by the addition of noninfectious V-Z antigen to cultures newly infected with V-Z virus. Several days leter, the V-Z virus in these cultures was titered. When leukocytes from donors immune to caricella were used, a significant decrease in V-Z titer, compared with controls, was noted. When leukocytes from donors susceptible to varicella were tested, no decrease in V-Z virus titer was found. A mixed population of lymphocytes and monocytes from immune donors was required to demonstrate inactivation of V-Z virus. The development of specific cell-mediated immunity to V-Z virus may play a role in termination of varicella and in prevention of second attacks of this disease.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=420798Documentos Relacionados
- Comparison of two methods for detecting varicella-zoster virus antibody with varicella-zoster virus cell-mediated immunity.
- Cell-mediated immunity to varicella-zoster virus measured by virus inactivation: mechanism and blocking of the reaction by specific antibody.
- Antibody-dependent cell-mediated cytotoxicity against varicella-zoster virus-infected targets.
- Varicella-zoster virus.
- Human serum antibodies to varicella-zoster virus thymidine kinase.