Cell cycle regulation of human histone H1 mRNA.
AUTOR(ES)
Plumb, M
RESUMO
A cloned genomic DNA fragment containing a human histone H1 gene has been used to analyze histone H1 gene expression in two human cell lines (HeLa S3 and WI-38). The cellular abundance of histone H1 mRNA was compared with that of core (H2A, H2B, H3, and H4) histone mRNAs as a function of the cell cycle: core and H1 histone mRNA levels are related both to each other and to the apparent rate of DNA synthesis and are rapidly destabilized after DNA synthesis inhibition. The use of three synchronization protocols, and of transformed and normal diploid cells in culture, suggests that the detected core and H1 histone mRNA levels are regulated by similar mechanisms in continuously dividing human cell lines and nondividing cells stimulated to proliferate.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=344691Documentos Relacionados
- Cell cycle regulation of mouse H3 histone mRNA metabolism.
- A histone H1 protein in sea urchins is encoded by a poly(A)+ mRNA.
- Individual regulation of the accumulation of H1 mRNA and core histone mRNAs in sea urchin embryos.
- Human La protein: a stabilizer of histone mRNA.
- Changes in the stability of a human H3 histone mRNA during the HeLa cell cycle.