Cell-Based Therapies for Myocardial Regeneration in Heart Failure: 20 Years of Debate

AUTOR(ES)

Machado-Júnior, Paulo André Bispo; Blume, Gustavo Gavazzoni; Francisco, Julio César; Guarita-Souza, Luiz César

FONTE

Braz. J. Cardiovasc. Surg.

DATA DE PUBLICAÇÃO

2020-08

RESUMO

ABSTRACT Oleuropein is one of the most abundant phenolic compounds present in olive leaves, and many studies have shown that this compound has important biological properties (anti-inflammatory, anti-atherogenic, anticancer, antimicrobial and antiviral) and that is why it has been gaining prominence in research. Oleuropein can be extracted from different sources using standard and unconventional methods, and can be recovered and purified (mainly by chromatographic techniques), for later use in several areas. The literature presents information about oleuropein alone in scientific research with different objectives, however, it was observed by the authors that studies that compile the existing information on these secoiridoides are very scarce and, therefore, this review was developed with the aim of providing current information to the scientific community, about the different techniques of extraction and purification of oleuropein, as well as the opportunities for applications and uses of this compound.

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