Catabolic Activities of Neisseria meningitidis: Utilization of Succinate1
AUTOR(ES)
Weiss, Emilio
RESUMO
When resting cells of Neisseria meningitidis group B were incubated with either succinate, fumarate, or malate, respiration and CO2 production were not significantly stimulated. These dicarboxylic acids were readily utilized, however, when they were added in association with a combination of α-ketoglutarate and aspartate or with glucose or with glutamate. The amounts of these substrates required for exogenous succinate utilization were relatively large. Both the α-ketoglutarate–aspartate combination and glutamate greatly stimulated succinate uptake into the cells, but glutamate was far more effective than the α-ketoglutarate–aspartate combination in eliciting exogenous succinate utilization. This difference is explained on the basis of evidence reported in another article that succinate derived from the α-ketoglutarate-aspartate mixture is metabolized more rapidly—and thus more rapidly dilutes the specific activity of added succinate—than the succinate derived from glutamate.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=250460Documentos Relacionados
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