Caspase Inhibitors Attenuate Superantigen-Induced Inflammatory Cytokines, Chemokines, and T-Cell Proliferation
AUTOR(ES)
Krakauer, Teresa
FONTE
American Society for Microbiology
RESUMO
Proinflammatory cytokines mediate the toxic effect of superantigenic staphylococcal exotoxins (SE). A pan-caspase inhibitor suppressed SE-stimulated T-cell proliferation and the production of cytokines and chemokines by human peripheral blood mononuclear cells. These data suggest that caspase inhibitors may represent a novel therapeutic modality for treating SE-induced toxic shock.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=404582Documentos Relacionados
- Coordinate Suppression of Superantigen-Induced Cytokine Production and T-Cell Proliferation by a Small Nonpeptidic Inhibitor of Class II Major Histocompatibility Complex and CD4 Interaction
- Pentoxifylline Inhibits Superantigen-Induced Toxic Shock and Cytokine Release
- CD38 expressed on human monocytes: A coaccessory molecule in the superantigen-induced proliferation
- Modulation of Mycoplasma arthritidis-derived superantigen-induced cytokine gene expression by dexamethasone and interleukin-4.
- Need for an External Proficiency Testing Program for Cytokines, Chemokines, and Plasma Markers of Immune Activation
