Carboxy-Terminal Proteolytic Processing of Helicobacter pylori Vacuolating Toxin
AUTOR(ES)
Nguyen, Viet Q.
FONTE
American Society for Microbiology
RESUMO
The vacA gene of Helicobacter pylori strain 60190 encodes a 1,287-amino-acid protoxin, which undergoes cleavage of a 33-amino-acid amino-terminal signal sequence and carboxy-terminal proteolytic processing to yield a mature secreted toxin. Several features of VacA suggest that it belongs to the autotransporter family of gram-negative bacterial secreted proteins. Based on matrix-assisted laser desorption ionization–time of flight mass spectrometric analysis, we calculate that the mature toxin has a mass of 88.2 ± 0.2 kDa and consists of approximately 821 amino acids.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=97915Documentos Relacionados
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