Caracterização molecular das cepas do Vírus Sincicial Respiratório identificadas nos anos de 2001 e 2002 em unidade de transplante de células tronco hematopoéticas / Molecular characterization of strains of Respiratory Syncytial Virus in Hematopoietic Stem Cell Transplant Unit identified in 2001 and 2002

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

Respiratory Syncytial Virus is recognized as the leading cause of nosocomial respiratory infection among recipients of hematopoietic stem cell transplant (HSCT) causing considerable morbity and mortality among theses patients. The aim this study was characterize the strains of Respiratory Syncytial Virus in recipients Hematopoietic Stem Cell Transplant Unit (HSCT) at Hospital das Clínicas, University of São Paulo Medical School during RSV season in symptomatic HSCT recipients at Hospital das Clínicas. The strains of RSV was typed (in group A or B) and genotyped. Of the seven strains analyzed from HSCT recipients during 2001, only two belonged to group B, the other five belonged to group A. Of these seven strains, three were closely related and were from outpatients. In 2002 , of the twelve strains analyzed, three belonged to group A and the other nine belonged to group B. Seven strains were closely related and were also from outpatients suggesting that nosocomial transmission in hospital-day was more likely. In conclusion, multiples genotypes of RSV co-circulated in the Hematopoietic Stem Cell Transplant units (ward and dayhospital) of Hospital das Clínicas between 2001 and 2002. Nosocomial transmission was more likely to occur at the HSCT Day-hospital as compared to the HSCT ward. Infection control practices should be also implemented at Day-hospital Units to avoid nosocomial transmission of RSV and other respiratory viruses in outpatient units.

ASSUNTO(S)

cross infection infecção hospitalar molecular epidemiology hospedeiro imunocomprometido bbone marrow transplantation epidemiologia molecular células-tronco hematopoéticas hematopoietic stem cells immunocompromissed host transplante de medula óssea infecções por respiratório sincicial/transmissão respiratory syncytial virus/transmission

ACESSO AO ARTIGO

Documentos Relacionados