Caracterização fenotípica de famílias com hipodontia no Hospital Universitário de Brasíia, Brasília-DF




Odontogenesis is the process of tooth development, resulting from epithelialectomesenchymal interactions. In humans, alterations in the dental development process are called dental anomalies. One of the most common of these is tooth agenesis, which is a change in number, due to the absence of dental germ formation. When agenesis involves up to six teeth, excluding the third molars, this condition is known as hypodontia. The aim of the present study was to describe the dental and oral cavity manifestations of patients and family members with hypodontia treated or undergoing treatment at the Dental Anomaly Clinic of the Dentistry Division of the Brasília University Hospital (HUB), of the University of Brasília (UnB). Nine families were studied, comprising a total of 60 individuals examined. The dominant form of autossomic inheritance was suggested for seven families; in six of the families expressiveness varied; in two others it was not possible to determine the form of inheritance. Also verified was the association of hypodontia with other dental anomalies, such as conoid teeth, supernumerary teeth, taurodontism, ectopic dental eruptions, and defective enamel development. Family I, diagnosed with ankyloglossy and number anomaly association, was investigated for the presence of a mutation in gene LGR-5 (leucine-rich repeat-containing G protein-coupled receptor 5). However, no mutation was found in the coding region of this gene.


ciencias da saude dentes anomalias

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