Caracterização das AgNORs no hepatocarcinoma : analise morfologica e quantitativa e comparação com a graduação de Edmondson-Steiner

AUTOR(ES)

Jose Telmo Valença Junior

DATA DE PUBLICAÇÃO

2001

RESUMO

The aim of this study was to evaluate the prognostic and diagnostic value of AgNOR and PCNA staining in biopsies of 34 liver cell carcinomas using an image analyzing system. The AgNOR number per nucleus and the relative AgNOR area, but not the PCNA index, showed a significant correlation with the histological tumor grade according to the classical and the modifiedEdmondson-Steiner s classification. Regarding univariate survival, only the grade of the classical Edmondson-Steiner s classification was of prognostic significance. The parameters sex, age, maximum tumor diameter, mean AgNOR number, total nuclear area and relative AgNOR area, nuclear area, PCNA index or the grade of the modified Edmondson-Steiner s classificationdid not reach statistical significanceregarding survival. By a factor analysis, two factors could be created, which could expIain together 72% of the variance of ali nine parameters included in the study. In a linear discriminate analysis, the AgNOR variabIes could separate between normalliver cells and cells ITomhigh grade or Iow grade carcinomas in 83,7% ofthe cases. Therefore, we think that the AgNOR technique can be usefully applied in biopsies of liver carcinomas for the differentialdiagnosis and tumor grading.

ASSUNTO(S)

cancer - prognostico cancer

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