Capilaroscopia na DMTC: um processo dinâmico associado ao envolvimento intersticial pulmonar e à gravidade de doença / Capillaroscopy in MCTD: a dynamic process associated to lung interstitial involvement and disease severity

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

For determining the clinical relevance of SD-pattern in MCTD, sixty-three MCTD patients (Kasukawa´s criteria) were consecutively selected. The main inclusion criterion was availability of previous nailfold capillaroscopy (NC) 5 years before inclusion. At entry, organ involvement and autoantibody evaluation were performed. The mean age and disease duration were 45.3 + 10 and 8.45 + 5.42 years, respectively. SD-pattern was observed in 41 patients at entry (65%) and in 45 at previous NC (71.5%), p = 0.20. Ten patients (16%) changed NC, 7 normalized, and 3 developed SD-pattern. Disease duration, number and frequency of organ involvement were similar in patients with and without SD-pattern. In contrast, analysis of each SD-pattern parameter revealed a significant lower frequency of moderate/severe avascular areas (AA) at entry compared to previous examination (26.5 vs. 53%, p = 0.013). Moreover, 76% of patients with interstitial lung disease (HRCT) had AA at entry, whereas only 24% of patients with this alteration did not have this NC finding (p = 0.017). Furthermore, reduced capillary density was frequently observed in patients taking immunosuppressive therapy than those without (66.7 vs. 33.3%, p = 0.001). NC in MCTD is a dynamic process and analysis of each SD-pattern parameter seems to be a good indicator of lung involvement and disease severity

ASSUNTO(S)

angioscopia microscópica/método lung diseases interstitial mixed connective tissue disease ribonucleoprotein u1 small nuclear/imunology microscopic angioscopy/methods doença mista do tecido conjuntivo doenças pulmonares intersticiais ribonucleoproteína nuclear pequena u1/imunologia

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