Campylobacter Jejuni Increases Transcribed Il-1 B and Causes Morphometric Changes in the Ileal Enterocytes of Chickens
AUTOR(ES)
Fonseca, BB, Ferreira Júnior, A, Santos, JP dos, Coelho, LR, Rossi, DA, Melo, RT, Mendonça, EP, Araújo, TG, Alves, RN, Beletti, ME
FONTE
Rev. Bras. Cienc. Avic.
DATA DE PUBLICAÇÃO
2016-03
RESUMO
Abstract Campylobacteriosis is a worldwide foodborne zoonosis disease caused by Campylobacter jejuni. This microorganism is considered a commensal bacterium in chicken hosts. C. jejuni produces epithelial cell modifications and induces a cytokine gene transcription innate immunity repertoire. In the present study, we describe the invasiveness, morphological cellular modifications, and transcript level expressions of innate immune cytokines from C. jejuni-inoculated chicken ileum explants. C. jejuni was internalized by epithelial ileum cells at 15 minutes postinoculation (p.i.) and was detected intracellularly for 4hs (p.i.). Inoculated explants displayed significant increases in cell height. C. jejuni induced a significant elevation of Transforming Growth Factor Beta 3 (TGF-b3) and Interleukin-1b (IL-1b) transcripts. In conclusion, C. jejuni is internalized in explanted epithelial ileum cells, produces morphological cell modifications, and induces gene transcription of both anti-inflammatory and pro-inflammatory cytokines.
Documentos Relacionados
- Campylobacter jejuni diarrhea model in infant chickens.
- A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity
- Increased Interleukin-1 (IL-1) and Imbalance between IL-1 and IL-1 Receptor Antagonist during Acute Inflammation in Experimental Shigellosis
- Norepinephrine increases the pathogenic potential of Campylobacter jejuni
- Campylobacter jejuni and Campylobacter coli serotypes isolated from chickens, cattle, and pigs.