Calcium and cell cycle progression: possible effects of external perturbations on cell proliferation.

AUTOR(ES)

Baran, I

RESUMO

Exit from the phase of cellular division appears to be driven by a calcium signal that triggers a cascade of events leading to the completion of mitosis. Here we propose a model that relates the dynamics of cytosolic calcium to progression through mitosis, G1 and G2 phases of the cell cycle. To this end, the assumption has been made that the transient rise ir cytosolic calcium concentration during mitosis is induced by inositol(1,4,5)triphosphate (IP3), which in turn is released at high levels of mitosis-promoting factor (MPF). On this basis, a system of ordinary differential equations is proposed to simulate the evolution of ten cell-cycle-specific molecular species, including cyclins A and B, MPF, IP3, Ca2+, the CaMKII holoenzyme, and the ubiquitination complex. The influence on the cell proliferation capacity exerted by external perturbations, like calcium microinjections, depletion of intracellular calcium stores, electromagnetic fields, or stimulation/inhibition of different calcium currents through the plasma membrane, can be studied by appropriate modulation of the parameters involved in the signal transduction pathway.

Documentos Relacionados

• Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.
• Immunocytochemical analysis of the coiled body in the cell cycle and during cell proliferation.
• Effects of c-myc expression on cell cycle progression.
• Cell Cycle Progression and Proliferation Despite 4BP-1 Dephosphorylation
• Sam68 exerts separable effects on cell cycle progression and apoptosis