Ca alginate as scaffold for iron oxide nanoparticles synthesis

AUTOR(ES)

Finotelli, P. V., Sampaio, D. A., Morales, M. A., Rossi, A. M., Rocha-Leão, M. H.

FONTE

Brazilian Journal of Chemical Engineering

DATA DE PUBLICAÇÃO

2008-12

RESUMO

Recently, nanotechnology has developed to a stage that makes it possible to process magnetic nanoparticles for the site-specific delivery of drugs. To this end, it has been proposed as biomaterial for drug delivery system in which the drug release rates would be activated by a magnetic external stimuli. Alginate has been used extensively in the food, pharmaceutical and biomedical industries for their gel forming properties in the presence of multivalent cations. In this study, we produced iron oxide nanoparticles by coprecipitation of Fe(III) and Fe(II). The nanoparticles were entrapped in Ca alginate beads before and after alginate gelation. XRD analysis showed that particles should be associated to magnetite or maghemite with crystal size of 9.5 and 4.3 nm, respectively. Studies using Mössbauer spectroscopy corroborate the superparamagnetic behavior. The combination of magnetic properties and the biocompatibility of alginate suggest that this biomaterial may be used as biomimetic system.

Documentos Relacionados

• SYNTHESIS AND NUCLEAR MAGNETIC RELAXATION PROPERTIES OF COMPOSITE IRON OXIDE NANOPARTICLES
• Synthesis, Characterization and Applications of Iron Oxide Nanoparticles - a Short Review
• Study of oxide nanoparticles as additives for vegetable lubricants
• Iron oxide based nanoparticles: synthesis and characterization
• Synthesis of nickel zinc iron nanoparticles by coprecipitation technique