c-Jun and junB immunoprofile in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glands / Estudo da imunoexpressão das proteínas C-JUN e JUNB em carcinoma adenóide cístico e adenocarcinoma polimorfo de baixo grau de malignidade de glândulas salivares
AUTOR(ES)
Roberto Anaximandro Garcia Rejas
DATA DE PUBLICAÇÃO
2008
RESUMO
Adenoid cystic carcinoma and polymorphous low grade are salivary gland neoplasms. ACC can arise in both, major or minor salivary glands. However, Polymorphous lowgrade adenocarcinoma, occurs specifically in minor salivary glands dispersed in the oral cavity. They share many common histologic features, as infiltrating solid, tubular and cribiform patterns and also high propensity for perineural invasion. Nevertheless, adenoid cystic carcinoma and polymorphous low grade are distinct types of adenocarcinomas with different prognosis, which occasionally may result in a diagnostic pitfall. C-jun and junB are family JUN members that may form homodimerizes or heterodimerizes with c-fos or other bzip proteins. Evidence for specific functions of AP-1 subunits was shown for c-jun and junB, which act antagonistically to control cell transformation, differentiation and expression of AP-1 depending on the target genes. However, the role of both of them is complex and it depends on cell type. The aim of this study was to determine immunohistochemistry of c -jun and junB expression in 13 cases of adenoid cystic carcinoma and 12 cases of polymorphous carcinoma low-grade adenocarcinoma of salivary glands. Moreover slides of normal mucosa were included and there were strong nuclei and cytoplasmic for junB and c-jun respectly. In the present study, independent of the histologic architecture, in both tumors shown many tumoral cells presented nuclear and cytoplasmic staining of c-jun and were absent to the protein junB. In polymorphous low-grade adenocarcinoma lesions expressed in a greater number cells staining than in the adenoid cystic carcinoma of the most lowgrade. According with this study and with some studies of the literature, the c-jun is expressed in low-grade tumors and seems to be related to cell differentiation more than with cell proliferation.
ASSUNTO(S)
polymorphous low-grade adenocarcinoma c-jun adenoid cystic carcinoma adenocarcinoma polimorfo de baixo grau de malignidade junb junb c-jun carcinoma adenóide cístico
Documentos Relacionados
- Galectin-3 immunoprofile in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glands
- Estudo da expressão imunoistoquímica da proteína galectina-3 associada à -catenina e ciclina D1 em carcinoma adenóide cístico e adenocarcinoma polimorfo de baixo grau de malignidade de glândulas salivares
- Expressão das proteinas c-jun, junb, JNK e pc-jun no carcinoma adenóide cístico e carcinoma epidermóide da cavidade bucal
- Evaluation of expression of MDM2, P53, P21WAF1 in adenoid cystic carcinoma and adenocarcinoma not otherwise specified of salivary glands
- Adipocyte differentiation selectively represses the serum inducibility of c-jun and junB by reversible transcription-dependent mechanisms.