Brain atrophy at onset and physical disability in multiple sclerosis
AUTOR(ES)
Rojas, Juan Ignacio, Patrucco, Liliana, Besada, Cristina, Bengolea, Laura, Cristiano, Edgardo
FONTE
Arq. Neuro-Psiquiatr.
DATA DE PUBLICAÇÃO
2012-10
RESUMO
The aim of this study was to investigate if brain atrophy in multiple sclerosis (MS) patients during the disease onset predicts long term disability. METHODS: MS patients with follow-up time of at least 7 years from disease onset and with baseline and second magnetic resonance 12 months later were included to measure brain atrophy. Expanded Disability Status Scale (EDSS) was categorized in three groups, EDSS=0, EDSS=1 and 2.5 and EDSS>2.5, and used as disability measure. RESULTS: Twenty-six patients were included. Mean atrophy during the first year in patients that reached an EDSS≥3 was -0.76±0.45 %, in patients with an EDSS between 1 and 2.5 was -0.59±0.56, while in patients with an EDSS of 0 it was -0.38±0.42 (p=0.003). DISCUSSION: Brain atrophy rates during the first year of disease were predictive of disease progression in our population.
Documentos Relacionados
- Brain atrophy in multiple sclerosis: therapeutic, cognitive and clinical impact
- Oligoclonal bands in the cerebrospinal fluid and increased brain atrophy in early stages of relapsing-remitting multiple sclerosis
- Onset symptoms of multiple sclerosis.
- THE SEASONAL INCIDENCE OF ONSET AND EXACERBATIONS IN MULTIPLE SCLEROSIS
- Abnormal brain scans in multiple sclerosis.