Block of Thalamic T-Type Ca2+ Channels by Ethosuximide Is Not the Whole Story
AUTOR(ES)
Crunelli, Vincenzo
RESUMO
On the basis of more than a decade of studies on the cellular effects of ethosuximide, currently, the most prudent view is that together with a block of the low threshold, T-type Ca2+ current, a reduction both of the noninactivating Na+ current, and the Ca2+-activated K+ current in thalamic and cortical neurones contribute to the overall therapeutic action of this antiabsence medicine.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=320973Documentos Relacionados
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