Block and activation of the pace-maker channel in calf Purkinje fibres: effects of potassium, caesium and rubidium
AUTOR(ES)
DiFrancesco, Dario
RESUMO
1. The effects of low concentrations of Cs+ (0·01-3mM) on the fully activated I-V relation īf(E) for the pace-maker current in calf Purkinje fibres have been investigated. The action of Cs+ is two-fold: in the negative region of the I-V curve Cs+ induces a channel blockade; on the other hand, at more positive potentials Cs+ can produce the opposite effect, i.e. a current increase.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1224792Documentos Relacionados
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