Biosynthesis of two dihydropyrrole-polyketides from a marine-derived Penicillium citrinum

AUTOR(ES)

Romminger, Stelamar, Pimenta, Eli F., Nascimento, Eduardo S., Ferreira, Antonio G., Berlinck, Roberto G. S.

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

09/10/2012

RESUMO

Experimentos de incorporação com precursores marcados com 13C foram realizados objetivando-se estabelecer a biossíntese de dois dihidropirróis N-acilados, (8E)-1-(2,3-dihidro1H-pirrol-1-il)-2-metildec-8-eno-1,3-diona (1) e 1-(2,3-dihidro-1H-pirrol-1-il)-2-metildecano1,3-diona (2), isolados de culturas de Penicillium citrinum de origem marinha. A biossíntese de ambos, 1 e 2, procede através da incorporação de acetato, metionina e ornitina.

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