Biosynthesis of penitrems and roquefortine by Penicillium crustosum.
AUTOR(ES)
Mantle, P G
RESUMO
Roquefortine and the penitrems were biosynthesised concurrently at an approximately equimolar rate by Penicillium crustosum after growth and sporulation. [14C]mevalonic acid was incorporated (15% efficiency) into the isoprenoid regions of the penitrem and roquefortine molecules to an extent consistent with their 6:1 molar ratio of isoprenoid components. [14C]penitrem A (specific activity, 3.4 X 10(2) mu Ci mmol-1) and 14C-penitrems B, C, and E readministered to young cultures were metabolically interconverted, indicating considerable metabolic flux, though generally directed towards penitrem A as the end product and suggesting a metabolic grid for the penitrem metabolites. Addition of bromide to the medium preferentially favored the production of bromo-analogs rather than the usual chloropenitrems.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=242489Documentos Relacionados
- Penitrem A and Roquefortine Production by Penicillium commune
- Novel metabolites from Penicillium crustosum, including penitrem E, a tremorgenic mycotoxin.
- Production of 5-hydroxy-7-methoxy-4-methylphthalide in a culture of Penicillium crustosum
- Biosynthesis of radiolabeled verruculogen by Penicillium simplicissimum.
- BIOSYNTHESIS OF NITRO COMPOUNDS I. : Nitrogen and Carbon Requirements for the Biosynthesis of β-Nitropropionic Acid by Penicillium atrovenetum